what is an icteric sample

What Is An Icteric Sample? Plasma, serum, urine and cerebrospinal fluid samples are defined as icteric if bilirubin in either form appears in increased concentration. The presence of bili- rubin may potentially interfere with measurements of other constituents in these samples.

What does icteric sample mean? Icterus, also known as jaundice, is used to describe the yellowish-greenish color observed in the sclera of the eyes or in plasma/serum samples of patients with very high concentrations of bilirubin.

What causes icteric blood sample? Icteric serum is caused by the presence of excess bilirubin in the blood stream as a result of increased production (pre-hepatic) or inappropriate excretion (hepatic and post-hepatic).

What color is an icteric blood sample? Blood is composed of cells and plasma (or serum), a liquid that is normally pale yellow in colour and transparent.

What does it mean if blood is icteric?

Icterus is also known as jaundice or yellow jaundice. It means that a yellow pigment is found in the blood and tissues.

What causes icterus?

The most common causes include gallstones and malignancy, such as pancreatic cancer and cholangiocarcinoma. In adults, scleral icterus can also occur due to liver dysfunction. Causes include drug-induced liver disease, parasites (liver fluke), viral hepatitis, and alcoholic and non-alcoholic cirrhosis.

What is the difference between jaundice and icterus?

Icterus is also known as jaundice or yellow jaundice. It refers to an excessive accumulation of a yellow pigment in the blood and tissues. When icterus has been present for any length of time, it will discolor many tissues and will become visible as jaundice on most body surfaces, including the skin.

What should happen when a blood sample is discovered to have icteric serum?

An icteric sample would have a spectral interference effect on the results. Volume displacement could occur with either lipemia or hyperproteinemia. Release of enzymes or analytes would occur in a hemolyzed sample.

How does icteric affect lab results?

Icteric index. The number reported under icterus is an estimation of the total bilirubin concentration in mg/dL rounded to the nearest whole number. The icterus index can be used to determine if there is hyperbilirubinemia, i.e. if the total bilirubin is increased, the icteric index should closely match the value seen.

What is lipemic?

Lipemia is defined as visible turbidity in serum or plasma samples due to the presence of lipoprotein particles, especially chylomicrons. The most common cause of turbidity is a high concentration of triglycerides [1,2].

What is lipemic sample?

Lipemia is a turbidity of the sample caused by accumulation of lipoprotein particles. As lipoproteins vary in sizes, not all classes contribute equally to the turbidity. The largest particles, chylomicrons, with sample size of 70–1000 nm, have the greatest potential in causing turbidity of the sample.

What is a Hemolyzed blood sample?

Abstract. The term hemolysis designates the pathological process of breakdown of red blood cells in blood, which is typically accompanied by varying degrees of red tinge in serum or plasma once the whole blood specimen has been centrifuged.

Why is lipemic sample not used in serologic testing?

Hemolytic and lipemic specimens may show variable results in antigen-antibody reactions, especially in nephelometric antibody assays. In general, lipemic specimens will interfere with enzymatic reaction assays.

Where do you see jaundice first?

The whites of the eyes are often the first tissues that you notice turning yellow when you develop jaundice. If the bilirubin level is only mildly high then this might be the only part of the body where you can detect a yellow colour. With higher levels of bilirubin, the skin also becomes yellow.

What is Icteric phase of hepatitis?

Phase 3 (icteric phase) – Patients may note dark urine, followed by pale-colored stools; in addition to the predominant gastrointestinal (GI) symptoms and malaise, patients become icteric and may develop right upper quadrant pain with hepatomegaly.

Why is jaundice called icterus?

Jaundice comes from the French jaune, meaning yellow, jaunisse meaning “yellow disease”. The medical term for it is icterus from the Greek word ikteros.

Why is icterus seen in upper sclera?

The majority of people affected by scleral icterus include infants and older adults. Causes of scleral icterus vary according to age. In newborns: Immature liver, absorption of bilirubin from the intestines, decreases in bowel movements, inherited genetic conditions, and viral hepatitis are potential causes.

What is bound to conjugated bilirubin?

Bilirubin conjugated with glucuronic acid also binds to albumin but with much lower affinity. Another form of bilirubin (probably conjugated), very tightly (probably covalently) bound to albumin, has been described.

What analytes are affected by icteric?

Results. Eight analytes increased (FRUC and Phos) or decreased (CHOLT, CREA, HDLc, PROT, TG, and UA) significantly when I ict increased. FRUC, HDLc, PROT, and UA showed a linear relationship when I ict increased.

What chemistry analytes are affected by hemolysis?

Two analytes greatly impacted by hemolysis are potassium and lactate dehydrogenase, in which their concentrations in erythrocytes are more than 20 times and 150 times higher than it is in serum, respectively.

What does gross lipemia mean?

Lipemia is visible when serum triglycerides are greater than 200 mg/dl. Gross lipemia implies hypertriglyceridemia and an increase in chylomicrons, VLDLs, or both. Hyperlipidemia is also diagnosed after measurement of serum cholesterol and triglyceride concentrations.

What is dog lipemia?

Dogs with hyperlipidemia, also called lipemia, have higher than normal amounts of triglycerides and/or cholesterol in their blood stream.

What is mild hyperlipidemia?

Hyperlipidemia means your blood has too many lipids (or fats), such as cholesterol and triglycerides. One type of hyperlipidemia, hypercholesterolemia, means you have too much non-HDL cholesterol and LDL (bad) cholesterol in your blood. This condition increases fatty deposits in arteries and the risk of blockages.

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